QS Study

Reticuloendothelial System

The combination of monocyte, mobile macrophages, fixed tissue macrophages and a few specialized endothelial cells in the bone marrow, spleen, and the lymph node is collectively called Reticuloendothelial system / Monocyte-macrophage system. It is the diffuse system constituting all phagocytic cells of the body except granulocytes including the cells lining the sinusoids of the spleen, lymph nodes, and bone marrow along with the fibroblastic reticular cells of hematopoietic tissues.


All these cells are originated from a monocytic stem cell.


They kill the foreign bodies and remove from the cell. Some of the reticuloendothelial cells found in the blood and in the general connective tissue are unusually large in size. These cells are concerned with blood cell formation and destruction, storage of fatty materials, and metabolism of iron and pigment, and they play a role in inflammation and immunity.

Table: Functions of Reticuloendothelial System