QS Study


Parkinson’s disease knows also as paralysis agitans, results from widespread destruction of that portion of the substantia nigra, the pars compacta, that sends dopamine-secreting nerve fibers to the caudate nucleus and putamen. It is a disorder of the nervous system. It results from damage to the nerve cells in a region of the brain that produces dopamine, a chemical that is vital for the smooth control of muscles and movement. The muscles of a person with Parkinson’s become weaker and the individual may assume an unusual posture.

Signs and Symptoms

It is characterized by –

  • Intention tremor,
  • Akinesia,
  • Bradykinesia,
  • Rigidity,
  • Postural disturbances.

It is caused by a loss of nerve cells in part of the brain called the substantia nigra. This leads to a reduction in a chemical called dopamine in the brain. After diagnosis, treatments can help relieve symptoms, but there is no cure.


No specific test exists to diagnose Parkinson’s disease. With L-dopa and L-dopa is converted in the brain into dopamine. We cannot use dopamine because it cannot pass through a blood-brain barrier. Your doctor will base a diagnosis on your symptoms, medical history, and a detailed physical examination.