QS Study

The syndrome of adult hypothyroidism is generally called myxedema. The term is used to refer specifically to the skin changes in this syndrome. This is a condition that occurs when your body doesn’t produce enough thyroid hormone.

Cause: The skin normally contains a variety of proteins combined with a polysaccharide, hyaluronic acid, and chondroitin sulfate. In hypothyroidism these complexes accumulate, promoting water retention and producing myxedema. A person ceasing to take their medication can cause this complication.

Signs and symptoms of severe myxedema can include: decreased breathing, hypothermia, low blood oxygen levels, high blood carbon dioxide levels, seizures etc.

Clinical features

(1) Face: Swollen, puffy and oedematous look of the face (Mongoloid appearance).

(2) Sex: impotency, amenorrhoea, etc.

(3) Mental condition: Impaired, dullness, loss of memory. (slow mentation)

(4) GIT and Metabolism:

  • ↓ Appetite,
  • ↓ Gastrointestinal motility so cause constipation,
  • ↓ BMR (Between -30 and -50),
  • ↓ Body temperature

(5) Blood:

  • ↓ Blood glucose level.
  • ↑ Sugar tolerance,
  • ↑ Serum cholesterol level,
  • Secondary anemia,
  • The rise of plasma protein.

(6) Heart and circulation and respiration:

  • ↓ Heart rate,
  • ↓ Stroke volume,
  • ↓ Cardiac output.

(7) Urine: Nitrogen excretion less.

(8) Thought: Processes slows down – lethargy, apathy.

(9) Skin: Dry and yellowish (Carotenemia) – Cold is poorly tolerated.

(10) Hair: Coarse and sparse.

(11) Voice: Husky and slow,

(12) Memory: poor,

(13) Mentation: Slow.


Administration of TH, as a result, the proteins are metabolized, and diuresis continues until the myxedema is cleaned. A myxedema coma requires instant entrance to a hospital. Treatment involves administering thyroid hormone substitute drug into a vein.