QS Study

Metabolic acidosis

Metabolic acidosis occurs when the body produces too much acid, or when the kidneys are not removing enough acid from the body. When blood or ECF HCO3 concentration decrease less than 24 mEq/L causes increase pH of the blood less than 7.35, then it is called metabolic acidosis. It can also occur when the kidneys are not removing enough acid from the body. This most often occurs with uncontrolled type 1 diabetes. Its causes are diverse, and its consequences can be serious, including coma and death.

Metabolic alkalosis

Metabolic alkalosis develops when your body loses too much acid or gains too much base. When plasma HCO3 concentration increase more than 24 mEq/L and thereby causes an increase in blood pH more than 7.45, then it is called metabolic alkalosis. This occurs as a consequence of a loss of H+ from the body or again in HCO3. In its pure form, it manifests as alkalemia (pH >7.40). The condition typically cannot last long if the kidneys are functioning properly.

This can be attributed to:

  • excess vomiting, which causes electrolyte loss
  • overuse of diuretics
  • adrenal disease
  • a large loss of potassium or sodium in a short amount of time
  • accidental ingestion of bicarbonate,