QS Study

Hypothyroidism (Deficiency of thyroid hormone)

Hypothyroidism is a situation in which the body lacks enough thyroid hormone. It is when the thyroid is underactive. It can affect your metabolism, mental functions, energy level, and bowel movements

Causes: The most familiar cause of thyroid gland breakdown is called autoimmune thyroiditis, a form of thyroid inflammation caused by the patient’s own immune system.

  1. Endemic colloid goiter,
  2. Thyroiditis,
  3. Idiopathic colloid goiter,
  4. Destruction of the thyroid gland by radiation,
  5. Surgical removal of the thyroid gland,
  6. Pituitary failure,
  7. Hypothalamic failure.

Symptoms – The signs and symptoms of hypothyroidism vary, depending on the severity of the hormone deficiency.

  • Extreme muscular sluggishness,
  • ↑ Body weight,
  • Depress the growth of hair and scaliness of the skin,
  • Constipation,
  • Development of a frog-like husks voice,
  • Fatigue and extreme somnolence.


  • Mental sluggishness,
  • ↓ Heart rate tip 4 Caulks’ output,
  • ↓ Cordial output.

Diagnostics tests in Hypothyroidism

(a) Measurement of plasma conc of ‘free’T4 (or T3) by RIA (radioimmune assay),

(b) Measurement of plasma cone, of TSH by RIA (Plasma conc. of TSH is greatly increased),

(c) BMR in myxedema range between 30 and 50

Treatment of hypothyroidism

Maintain a steady level of TH activity by daily oral tablet containing thyroxine.