QS Study

The process of formation and maturation of sperm from primordial germ cell in the male is tailed spermatogenesis. It is the production and development of sperm. This procedure begins at puberty and continues for the remainder of a male’s life.

Advances in the supervision of male sterility will only happen when our understanding of the regulation of spermatogenesis has progressed further. There are substantial data emerging to indicate that this regulation occurs at two major levels: (i) hormonal and endocrine and (ii) paracrine/autocrine.

Fig: Hormonal Regulation of Spermatogenesis

Hormones that regulate spermatogenesis are:

(i) Gonadotropin-releasing hormone (GnRH) of hypothalamus acts on anterior pituitary and causes releasing of gonadotropin hormone.

(ii) Follicle stimulating hormone (FSH) from the anterior pituitary gland acts on the testes.

(iii) Luteinizing hormone (LH) from the anterior pituitary gland acts on testes.

(iv) Testosterone from Leydig cells Inhibits the hypothalamus and pituitary.

(v) Inhibin from Sertoli cells Inhibits the hypothalamus and pituitary.

(vi) Estrogen formed from testosterone by Sertoli cells and probably essential.

(vii) Growth hormone promotes early division of spermatogonia.

The endocrine regulation of spermatogenesis is accomplished via a classic negative feedback loop involving interactions between the hypothalamus, pituitary, and testis