QS Study

Glucagon with function

Glucagon is glycogenolytic, gluconeogenic, lipolytic and ketogenic. It is a hormone that works with other hormones and bodily functions to organize glucose levels in the blood. It plays a dynamic function in allowing the body to control the utilization of glucose and fats. It is used as a medication to treat a number of health conditions.

(A) Effects on glucose metabolism:

  • ↑ Glycogenolysis.
  • ↑ Gluconeogenesis.
  • ↓ Glycogen synthesis.
  • ↓ Glucose oxidation.

Net effect –

  • ↑ Blood glucose
  • ↑ Lypolysis (liver and adipose tissue)
  • ↑ Ketogenesis.

(B) On CVS:

  • ↑ Heart rate
  • ↑ Force of contraction.

Fig: Glucagon with Function

(C) Other effects of glucagon:

When the conc of glucagon increase more than the normal level, it causes –

(1) It activates adipose cell lipase, making increase quantities of fatty acids available to the energy systems of the body.

(2) It also inhibits the storage of triglyceride in the liver. Which prevents the liver from removing fatty acids from the blood.

(3) Glucagon works in a process known as gluconeogenesis, which is the production of glucose in the amino acid molecules.

The effect of glucagon is to make the liver release the glucose it has stored in its cells into the bloodstream, with the net effect of increasing blood glucose.