QS Study

The liver is the largest solid organ and the largest gland in the human body. It is located below the diaphragm in the right upper quadrant of the abdominal cavity. It is the largest visceral structure in the abdominal cavity and the largest gland in the human body.

Development of liver –

(1) The liver develops from an endodermal bud, which is the outgrowth of the distal part of the foregut.

(2) This endodermal bud (hepatic bud) penetrates the mesoderm (septum transversum).

(3) By enlarging, it forms the pars hepatica and paralytic.

(4) The pars hepatica divides into right and left parts and thus the right and left lobes of the liver are formed.

(5) The fate of the vitelline and umbilical veins during the development of the human liver.

Fig: Development of the Liver

Development of different components of the liver:

(i) Parenchyma and bile capillaries – Endodermal.

(ii) Sinusoids – Mesodermal.

(iii) Capsule, stroma – Mesodermal.

(iv) Kupffer cell- from bone marrow monocyte.