QS Study

Development and Structure of the Prostate

The prostate is an accessory gland of the male reproductive system. The major function of the prostate is to create fluid for semen, which transports sperm throughout the male orgasm. This is the fluid that carries sperm.

Development of the prostate

  • Glandular part: Glandular part of the prostate develops from the solid outgrowth from the pelvic part of the urogenital sinus. Fetal testosterone stimulates urogenital sinus mesenchyme through androgen receptors. Urogenital sinus mesenchyme acts on the overlying epithelium to stimulate cell proliferation.
  • Fibromuscular part: It develops from the splanchnic mesoderm surrounding the urogenital sinus. Urogenital sinus epithelium then forms prostate ductal progenitor, the prostatic buds. Prostatic buds then grow into the urogenital sinus mesenchyme.

Structure of the prostate

The prostate is structurally a fibromusculoglandular organ. The fibrous coat and the fibrous stroma with the musculature form the basic structure of the organ and the glandular tissues are distributed within them.

The histological section shows two well defined concentric zones separated by an ill-defined irregular capsule. Prostatic urethra traverses vertically downward via the gland in the junction of its anterior one-third and posterior two-third and opens on the anterior surface just above the apex.

Fig – Structure of prostate

The outer larger zone is composed of large branched glands, the ducts of which curve backward and open mainly into the prostatic sinuses. The ducts of these glands arch backward and open in the prostatic sinus below the colliculus seminalis.

The inner smaller zone is composed of submucosal glands opening in the prostatic sinuses and a group of short, simple mucosal glands surrounding the upper part of the urethra. Deep to these glands are simple mucosal glands (suburethral glands), that are short and open all around the urethra above the level of colliculus seminalis.