QS Study

Conn’s Syndrome

Primary aldosteronism or Conn’s syndrome

Conn’s syndrome is a disease in which one or both adrenal glands produce too much aldosterone as a consequence of a tumor. Hyperaldosteronism due to primary adrenal disease is called ‘Primary aldosteronism”, or Conn’s syndrome. It is an endocrine disorder characterized by extreme secretion of the hormone aldosterone from the adrenal glands.


(i) Unilateral and bilateral adrenal hyperplasia,

(ii) Adrenal carcinoma,

(iii) An adenoma of the zona glomerulosa,

(iv) GRA (Glucocorticoid-remediable aldosteronism)

Sign and Symptoms:

High blood pressure (hypertension) is the main, and often the only, symptom. Other symptoms may include:

Frequent urination, Increased thirst, Fatigue, Palpitations, Muscle cramps, Tingling, Moderate to severe high blood pressure etc.

Clinical feature – Hypertension, tetany, polyuria, hypokalemia, and alkalosis.

Treatment – Surgical removal of the tumor or of most of the adrenal tissue. The goals of treating primary aldosteronism are to lower blood pressure to normal or near normal levels, decrease blood aldosterone levels, and resolve any electrolyte imbalances. Diagnosis and treatment of primary aldosteronism are vital because people with this form of high blood pressure have a higher risk of heart disease and stroke