QS Study

Cerebro Spina Fluid (CSF)

Cerebro Spina Fluid is a clear colorless modified tissue fluid formed by ultrafiltration of plasma in Cerebro Spina Fluid. It is a clear, colorless body fluid found in the brain and spinal cord. The CSF obtained during a lumbar puncture is analyzed to detect disease.

Physical characteristics and composition:


  • Mainly choroid plexus of the lateral ventricles and partly of 3rd and 4th ventricle.
  • Ependymal Cells lining the ventricles.
  • Brain substance through the perivascular space.
  • Capillaries on the surface of the brain.


From the lateral ventricle, CSF enters the 3rd ventride via foramen of Monro. Then through cerebral aqueduct enter onto 4th ventricle. Finally, enter the subarachnoid space of brain and spinal cord via foramen of Magendie and foramen of luschka. CSF moves in a single outward direction from the ventricles, but multi-directionally in the subarachnoid space


Mainly through arachnoid villi that project into the dural venous sinuses especially superior sagittal sinus. The villi tend to group together to form elevation known as arachnoid granulations. Villi are diverticulum of Subarachnoid space.

Functions – a Primary function of CSF is to cushion the brain within the skull and serve as a shock absorber for the central nervous system.

  1. Cushions and protects the central nervous system from trauma.
  2. Provides mechanical buoyancy and support for the brain.
  3. Nourishes the central nervous system.
  4. Removes metabolites from the central nervous system.
  5. Serves as a pathway for pineal secretion to reach pituitary gland.
  6. Serves as a reservoir and assists in the regulation of the content of skull.
  7. CSF also circulates nutrients and chemicals filtered from the blood and removes waste products from the brain.