QS Study

Brunner’s gland – These are the characteristics of the duodenum which are compound racemose in type present in submucous coat and secrets mostly mucous. The main function of these glands is to produce a mucus-rich alkaline secretion. They are histologically indistinguishable from the glands located in the distal gastric mucosa and periampullary region. It is the glands in the submucosal layer of the duodenum, secreting an alkaline fluid into the small intestine.

Importance of Brunner’s gland

They secrete mucous which is alkaline in nature. This mucous protects the duodenal muscous membrane against the effect of gastric juice and brings the intestinal contents to the optimum pH for the action of the pancreatic enzyme. It does not have any enzymes but it helps in protecting the inner walls of the intestine from the acidic activity of the chyme received from the stomach.

Fig:¬†Brunner’s gland


  • protect the duodenum from the acidic content of chyme (which is introduced into the duodenum from the stomach);
  • provide an alkaline condition for the intestinal enzymes to be active, thus enabling absorption to take place;
  • lubricate the intestinal walls.