Sulphonation of –NH2 group:
Aniline at first produces aniline hydrogen sulphate by reacting with sulphuric acid, which if heated at I80-200°C produces p-amino benzene sulphonic acid or Sulphanilic acid. Nature abounds with nitrogen compounds, many of which occur in plants and are referred to as alkaloids.
Sulphanilic acid is used in:
- Production of sulfa drugs, e.g. sulfaguadin, sulfathiozole, sulfadiazin, sulfapyridine etc.
- Sulfaguadin is used in stomach diseases.
- Sulfadiazin & sulfathiazole are used as anti-microbial agent.
- Sulfapyridine is used in the treatment of pneumonia.