What is Pharmacokinetics? - QS Study
QS Study

The term pharmacokinetics refers to the mathematical modelling of the rate and completeness of the four components of ADME in order to be able to predict blood levels of drug that would arise from any defined dosage regimen.

Pharmacokinetics describes, in a quantitative manner, the passage of drugs through the body. A series of distinctive parameters such as bioavailability, volume of distribution and clearance are used to describe:

  • The rate and extent of drug absorption into the blood stream
  • The rate and extent of drug movement out of blood into the tissues
  • The rate of drug removal from the body

 

These parameters can then be used to predict the blood concentration of drug that will arise with any given dosage regime.

A diverse range of students will have some exposure to PKs.

– For clinically oriented students – medicine, pharmacy etc – the main interest will be in calculating dosage regimes for individual patients.

– Basic science students – pharmacology, pharmaceutical sciences etc – need to understand the uses that clinicians make of pharmacokinetic concepts, but they will also need to appreciate why determining the kinetic properties of a new drug or formulation is so important in the drug development process.

 

Most of the topics covered will be relevant to both drug development and clinical practice, but the introduction to each chapter will indicate the area(s) of relevance for the material.