Gastrin - QS Study
QS Study

Gastrin

When we eat, a complex set of reactions in the body aid digest and absorb the food. Gastrin is one of the hormones liable for the procedure. It is placed in the G cells in the lining of the stomach and upper small intestine. It also has a vital trophic or growth-promoting influence on the gastric mucosa. It is straight liable for the discharge of gastric acid, which breaks down the proteins in the food you eat.

Origin – G cells of antrum and duodenum.

A stimulus for gastrin secretion: Increased vagal discharge (mediated by a gastrin-releasing peptide, GRP).

– Digestive products (i.e. amino acids, polypeptides).

– Calcium salts.

– Gastric distension.

Inhibition of gastrin release –

  • Acidification of pyloric glandular mucosa to pH <1.5.
  • Secretin, GIP, VIP, glucagon, and calcitonin.

Physiologic roles – Gastrin is a hormone produced by the stomach, which stimulates the release of gastric acid. Gastric acid helps the body absorb some of the vitamins in the food and kills much of the bacteria naturally present in food. This helps protect the gut from infection.

  1. Stimulation of HCl secretion by parietal cells,
  2. Stimulation of pepsinogen secretion by chief cells,
  3. Stimulation of growth of gastric mucosa,
  4. Increasing gastric blood flow,
  5. Promotion of contraction of the circular muscle of stomach,
  6. Increasing tone (contraction) in the lower oesophageal sphincter,
  7. A weak stimulus for the secretion of pancreatic enzymes and HCO3
  8. Stimulation of histamine release from enterochromaffin-like cells.