QS Study

Factors for Hemoglobin (Hb) Synthesis

Hemoglobin (Hb) may be defined as a vital conjugated protein present inside the Red Blood Cells (RBC). It is the protein molecule in red blood cells that bear oxygen from the lungs to the body’s tissues and returns carbon dioxide from the tissues back to the lungs.

Hemoglobin synthesis necessitates the coordinated construction of heme and globin. Heme is the prosthetic group that mediates reversible binding of oxygen by hemoglobin. Globin is the protein that surrounds and protects the heme molecule.

Fig: Hemoglobin (Hb) Synthesis

Factors for Hb synthesis

  1. Deit: 1st class protein (A.A) for globin synthesis.
  2. Metals: These include iron, copper, cobalt, and manganese. Fe, Cu, Mg, Co, N for heam synthesis.
  3. Vitamin: Vit-B12, Vit-C, Folic acid, pyridoxine. The vitamins of special importance for Hemoglobin formation are vitamin B12, folic acid, ascorbic acid, nicotinic acid, and pyridoxine.
  4. Protoporphyrin: Anterior pituitary and the thyroid gland take an active part in Hemoglobin formation.
  5. Erythropoietin: The activity of erythroid marrow has been found to be controlled by a hormonal agent produced in the kidney and called erythropoietic factor.
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