Production of Aspirin and Paracetamol - QS Study
QS Study

Production of Aspirin and Paracetamol

Acid anhydride is used as acylation reagent. When phenol is heated with Carbon dioxide (CO2) and Sodium hydroxide (NaOH) at high temperature and high pressure Salicylic acid is produced. Then salicylic acid is refluxed with ethanoic anhydride to produce aspirin. Aspirin is the ester of salicylic acid & ethanoic anhydride.

4-aminophenol reacts with ethanoic anhydride to produce paracetamol (4-hydro acetinalide)

Aspirin is both an organic ester and an organic acid. It is used extensively in medicine as a pain killer (analgesic) and as a fever-reducing drug (antipyretic). When ingested, acetylsalicylic acid remains intact in the acidic stomach, but in the basic medium of the upper intestinal tract, it hydrolyzes forming the salicylate and acetate ions. However, its additional physiological effects and biochemical reactions are still not thoroughly understood.